Letzte Änderung: 21. Januar 2024

Haeckel, R., Adeli, K., Jones, G., Sikaris, K., Wosniok, W. (2023): Definitions and major prerequisites of direct and indirect approaches for estimating reference limits. Clin Chem Lab Med 61 (21), 402-406.

Haeckel, R., Ammer, T., Wosniok, W., Krebs, A., Torge, A., Özcürümez, M., Bertram, A. (2023): Age-and sex-specific reference intervals of total cholesterol, LDL cholesterol, HDL cholesterol and non-HDL cholesterol. Comparison of two algorithms for the indirect estimation of reference intervals. J Lab Med 47 (2), 55-62.

Mändle, A., Brannath, W., Wosniok, W. (2023): Statistical optimization of expensive multi-response black-box functions. arXiv:2303.05992v1 [stat.CO] 10 Mar 2023

Haeckel, R., Wosniok, W. (2021): The importance of correct stratifications when comparing directly and indirectly estimated reference intervals. Clin Chem Lab Med 59 (10) , 1628-1633.

Haeckel, R., Wosniok, W. (2021): Reply to the letter of Katayev and Fleming. J Lab Med 2021; DOI 10.1515/labmed-2021-0126.

Kruse-Plass, M.; Hofmann, F.; Wosniok, W.; Schlechtriemen, U.; Kohlschütter, N. (2021): Pesticides and pesticide-related products in ambient air in Germany. Environmental Sciences Europe; 33 (1).

Haeckel, R.; Carobene, A.; Wosniok, W. (2021): Problems with estimating reference change values (critical differences). Clinica Chimica Acta; 52 437-440.

Haeckel, R.; Wosniok, W.; Streichert, T. (2021): Review of potentials and limitations of indirect approaches for estimating reference limits/intervals of quantitative procedures in laboratory medicine. J Lab Med 2021; 45(2) 35-53.

Haeckel, R.; Wosniok, W.; Torge, A.; Junker, R.; Bertram, A; Krebs, A.; Özcürümez, M.; Orth, M.; Streichert, T. (2021): Age and sex dependent reference intervals for random plasma/serum glucose concentrations related to different sampling devices and determined by an indirect procedure with data mining. J Lab Med 2021; 45(2) 95-101

Haeckel, R.; Wosniok, W.; Torge, A.; Junker, R.(2020): Reference limits of high-sensitive cardiac troponin T indirectly estimated by a new approach applying data mining. A special example for measurands with a relatively high percentage of values at or below the detection limit. J Lab Med 2020; aop. https://doi.org/10.1515/labmed-2020-0063

Haeckel, R.; Wosniok, W.; Torge, A.; Junker, R.; Bertram, A.; Krebs, A.; Özcürümez, M., Orth, M.;Streichert, T. (2020): Age and sex dependent reference intervals for random plasma/serum glucose concentrations related to different sampling devices and determined by an indirect procedure with data mining. A special example for measurands with a relatively high percentage of values at or below the detection limit J Lab Med 2021; 45(2): 87–94. https://doi.org/10.1515/labmed-2020-0064

Haeckel, R.; Wosniok, W; Torge, A.; Junker, R. (2020): Age- and sex-dependent reference intervals for uric acid estimated by the truncated minimum chi-square (TMC) approach, a new indirect method. J Lab Med 44(3) 157–163

Haeckel, R.; Wosniok, W; Streichert, T. (2020): The difference between reference interval and reference range. J Lab Med 44(3) 173

Wosniok, W.; Nickel, S.; Schroeder, W. (2020): Development of the software tool Sample Size for Arbitrary Distributions and exemplarily applying it for calculating minimum numbers of moss samples used as accumulation indicators for atmospheric deposition. Environ Sci Eur 32, 9. https://doi.org/10.1186/s12302-020-0290-1

Wosniok, W.; Nickel, S.; Schroeder, W. (2019): Sample Size for Arbitrary Distributions using the example of mosses as indicators for atmospheric deposition. GEFAHRSTOFFE 79 Nr. 11-12, 451-459

Wosniok, W.; Haeckel, R. (2019): A new indirect estimation of reference intervals: truncated minimum chi-square (TMC) approach. Clin Chem Lab Med 57(12) 1933-1947. https://doi.org/10.1515/cclm-2018-1341

Dieckmann, K.-P., Radtke, A., ..., Wosniok, W. (2019): Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study. J Clin Oncol, https://doi.org/10.1200/JCO.18.01480

Schulte, K.F., Dänhardt, A., Hufnagl, M., Siegel, V., Neudecker, T., Wosniok, W., Temming, A.(2018): Not Easy To Catch: New insights into factors affecting catch rates of partly pelagic brown shrimps (Crangon crangon L.). ICES Journal of Marine Science, 75(4), 1318-1328.

Haeckel, R., Wosniok, W., Gurr, E. (2017): Diagnostic efficiency in models for permissible measurement uncertainty. Journal of Laboratory Medicine, 41(6), 309-315. DOI: 10.1515/labmed-2017-0041

Wullschleger, A., Wosniok, W., Timm, J., Heinze, M. (2017): Challenges and Perspectives in Bridging In- and Outpatient Sectors: The Implementation of Two Alternative Models of Care and Their Effect on the Average Length of Stay. Front. Psychiatry, 05 October 2017. DOI: 10.3389/fpsyt.2017.00196.

Dieckmann, K.-P., Radtke, A., Spiekermann, M., Balks, T., Matthies, Becker, C. P., Ruf, C., Oing, C., Oechsle, K., Bokemeyer, C., Hammel, J., Melchior, S., Wosniok, W., Belge, G. (2017b): re: “Serum Levels of MicroRNA miR-371a-3p: A Sensitive and Specific New Biomarker for Germ Cell Tumours” (vol 71, pg 213, 2017). European Urology 71(5), E161. ISSN: 0302-2838. DOI: 10.1016/j. eururo.2017.01.041.

Dieckmann, K.-P., Radtke, A., Spiekermann, M., Balks, T., Matthies, Becker, C. P., Ruf, C., Oing, C., Oechsle, K., Bokemeyer, C., Hammel, J., Melchior, S., Wosniok, W., Belge, G. (2017a): Serum Levels of MicroRNA miR-371a-3p: A Sensitive and Specific New Biomarker for Germ Cell Tumours“. European Urology 71(2), 213–220. ISSN: 0302-2838. DOI: 10.1016/j.eururo.2016.07.029.

Nickel, S. Schröder, W., Wosniok, W., Harmens, H. et al. (2017): Modelling and mapping heavy metal and nitrogen concentrations in moss in 2010 throughout Europe by applying Random Forests models. Atmospheric Environment 156, 146–159. ISSN: 1352-2310. DOI: {10.1016/j.atmosenv.2017.02.032}.

Schröder, W., Nickel, S., Schönrock, S., Schmalfuss, R., Wosniok, W., Meyer, M. et al. (2017): Bioindication and modelling of atmospheric deposition in forests enable exposure and effect monitoring at high spatial density across scales. Annals of Forest Science 74(2). ISSN: 1286-4560. DOI: 10.1007/s13595-017-0621-6.

Haeckel, R., Wosniok, W., Arzideh, F., Zierk, J., Gurr, E., Streichert, T. (2017): Critical comments to a recent EFLM recommendation for the review of reference intervals. Clin Chem Lab Med 55(3), 341–347. ISSN: 1434-6621. DOI: 10.1515/cclm-2016-1112.

Haeckel, R., Wosniok, W., Gurr, E., Postma, T., Streichert, T. (2017): Quantity quotient reporting versus z-value for standardizing quantitative laboratory results. J Lab Med 2017 41(2) 93–97.

Haselsteiner, A.F., Ohlendorf, J.H., Wosniok, W., Thoben, K.-D. (2017): Deriving environmental contours from highest density regions. Coastal Engineering 123 42–51.

Kruse-Plass, M., Hofmann, F., Kuhn, U., Otto, M., Schlechtriemen, U., Schröder, B., Vögel, R., Wosniok, W. (2017): Reply to the EFSA (2016) on the relevance of recent publications (Hofmann et al. 2014, 2016) on environmental risk assessment and management of Bt.maize events (MON810, Bt11 and 1507). Environ Sci Eur (2017) 29:12. DOI 10.1186/s12302-017-0106-0.

Lang, T., Kruse, R., Haarich, M., Wosniok, W. (2017): Mercury species in dab (Limanda limanda) from the North Sea, Baltic Sea and Icelandic waters in relation to host-specific variables. Marine Environmental Research 124, 32-40, Special Issue: SI. http://dx.doi.org/10.1016/j.marenvres.2016.03.001 .

Lang, T., Feist, S.W., Stentiford, G.D., Bignell, J.P., Vethaak, A.D., Wosniok, W. (2017): Diseases of dab (Limanda limanda): Analysis and assessment of data on externally visible diseases, macroscopic liver neoplasms and liver histopathology in the North Sea, Baltic Sea and off Iceland. Marine Environmental Research 124, 61-69, Special Issue: SI. DOI: 10.1016/j.marenvres.2015.12.009

Gabriel, K.M.A, Kuechly, H.U., Falchi, F., Wosniok, W., Hölker, F. (2017): Resources of dark skies in German climatic health resorts. Int J Biometeorol 61(1), 11-22. DOI 10.1007/s00484-016-1187-y.

Vethaak, A.D., Davies, I.M., Thain, J.E., Gubbins, M.C., Martínez-Gómez, C., Robinson, C.D., Moffat, C.F., Burgeot, T., Maes, T., Wosniok, W., Giltrap, M., Lang, T., Hylland, K. (2017): Integrated indicator framework and methodology for monitoring and assessment of hazardous substances and their effects in the marine environment. Marine Environmental Research 124, 11-20. DOI 10.1016/j.marenvres.2015.09.010

Zutt, M., Rudolph, H., Kaune, K.M., Wosniok, W., Gärtner, U., Linke, R.(2016): Myocardial scintigraphy – a method for detecting cardiac comorbidity in psoriasis patients? Journal of the German Society of Dermatology, DOI 10.1111/ddg.12892.

Hofmann, F., Kruse-Plass, M., Kuhn, U., Otto, M., Schlechtriemen, U., Schröder, B., Vögel, R., Wosniok, W. (2016): Accumulation and variability of maize pollen deposition on leaves of European Lepidoptera host plants and relation to release rates and deposition determined by standardised technical sampling. Environ Sci Eur (2016) 28:14. DOI 10.1186/s12302-016-0082-9 .

Haeckel, R., Wosniok, W., Arzideh, F. (2016): Equivalence limits of reference intervals for partitioning of population data. Relevant differences of reference limits. LaboratoriumsMedizin 40 (3) 199–205, DOI 10.1515/labmed-2016-0002.

Schröder, W., Nickel, S., Schönrock, S., Meyer, M., Wosniok, W., Harmens, H., Frontasyeva, M.V, et al. (2016): Spatially valid data of atmospheric deposition of heavy metals and nitrogen derived by moss surveys for pollution risk assessments of ecosystems. Environ Sci Pollut Res. doi:10.1007/s11356-016-6577-5 .

Dieckmann, K.-P., Spiekermann, M., Balks, T., Ikogho, R., Anheuser, P., Wosniok, W., Loening, T., Bullerdiek, J., Belge, G. (2016): MicroRNA miR-371a-3p – A Novel Serum Biomarker of Testicular Germ Cell Tumors: Evidence for Specificity from Measurements in Testicular Vein Blood and in Neoplastic Hydrocele Fluid. Urol Int. DOI: 10.1159/000444303 .

Haeckel, R., Wosniok, W., Gurr, E. and Peil, B. (2016): Supplements to a recent proposal for permissible uncertainty of measurements in laboratory medicine. J Lab Med aop. http://dx.doi.org/10.1515/labmed-2015-0112 .

Hoffmann, G., Lichtinghagen, R., Wosniok, W. (2016): Simple estimation of reference intervals from routine laboratory data. J Lab Med 39(6) 389-402. http://dx.doi.org/10.1515/labmed-2015-0104 .

Wullschleger, A., Wosniok, W., Timm, J., Heinze, M. (2015): Subscription Rates of Psychiatric Patients to an Integrated Care Program in the Context of a Psychiatric Model Project. Psychiatrische Praxis, Oktober 2015. http://europepmc.org/abstract/MED/26488266

Hoffmann, G., Lichtinghagen, R., Wosniok, W. (2015): Ein einfaches Verfahren zur Schätzung von Referenzintervallen aus routinemäßig erhobenen Labordaten. J Lab Med 2015(11). http://dx.doi.org/10.1515/labmed-2015-0082.

Schumacher, T.C., Aminian, A., Volkmann, E., Lührs, H., Zimnik, D., Pede, D., Wosniok, W., Treccani, L., Rezwan, K. (2015): Synthesis and mechanical evaluation of Sr-doped calcium-zirconium-silicate (baghdadite) and its impact on osteoblast cell proliferation and ALP activity. Biomedical Materials, Volume 10, Number 5, October 2015. http://dx.doi.org/10.1088/1748-6041/10/5/055013.

Kloth, L., Gottlieb, A., Helmke, B., Wosniok, W., Löning, T., Burchardt, K., Belge, G., Günther, K., Bullerdiek, J. (2015): HMGA2 expression distinguishes between different types of postpubertal testicular germ cell tumour. The Journal of Pathology: Clinical Research, 1: 239–251. doi: 10.1002/cjp2.26

Keddig, N., Schubert, S., Wosniok, W. (2015): Optimal test design for binary response data: the example of the fish embryo toxicity test. Environmental Sciences Europe (2015) 27:15. DOI 10.1186/s12302-015-0046-5.

Haeckel, R., Wosniok, W., Postma, T. (2015): Quantity quotient reporting. Comparison of various models. Clin Chem Lab Med (CCLM). ISSN (Online) 1437-4331, ISSN (Print) 1434-6621, DOI: 10.1515/cclm-2015-0101, May 2015

Haeckel, R., Wosniok, W., Streichert, T. (2015): Optimizing the use of the “state-of-the-art” performance criteria. Clin Chem Lab Med 2015; 53(6) 887–891. DOI 10.1515/cclm-2014-1201.

Haeckel, R., Wosniok, W., Gurr, E., Peil, B. (2015): Permissible limits for uncertainty of measurement in laboratory medicine. Clin Chem Lab Med 2015. doi:DOI 10.1515/cclm-2014-0874.

Hofmann, F., Otto, M., Wosniok, W. (2014): Maize pollen deposition in relation to distance from the nearest pollen source under common cultivation - results of 10 years of monitoring (2001 to 2010). Environmental Sciences Europe 2014, 26:24. doi:10.1186/s12302-014-0024-3.

Waerner, C., Wosniok, W., Diekmann, M. (2014): River corridor plants in North-western Germany are threatened by small population size and short-term environmental events. TUEXENIA 34, 233-245. doi:10.14471/2014.34.009

Klemke, M., Müller, M.H., Wosniok, W., Markowski, D.N., Nimzyk, R., Helmke, B.M., Bullerdiek, J. (2014): Correlated Expression of HMGA2 and PLAG1 in Thyroid Tumors, Uterine Leiomyomas and Experimental Models. PLoS ONE 9(2): e88126. doi:10.1371/journal.pone.0088126

Sander, A., Wosniok, W., Gabel, D. (2014): Case numbers for a randomized clinical trial of boron neutron capture therapy for Glioblastoma multiforme. Appl. Radiat. Isotopes 88 (2014) 16-19, http://dx.doi.org/10.1016/j.apradiso.2013.11.092i

Haeckel, R., Wosniok, W., Klauke, R. (2013): Comparison of ordinary linear regression, orthogonal regression, standardized principal component analysis, Deming and Passing-Bablok approach for method validation in laboratory medicine. J Lab Med 2013; 37(3): 147–163. DOI: 10.1515/labmed-2013-0003.

Grütjen, F., Lang, T., Feist, S., Bruno, D., Noguera, P., Wosniok, W. (2013): Hyperpigmentation in North Sea dab Limanda limanda. I. Spatial and temporal patterns and host effects. Dis Aquat Org 103: 9–24. doi: 10.3354/dao02554.

Haeckel, R., Wosniok, W., Kratochvila, J., Carobene, A. (2012): A pragmatic proposal for permissible limits in external quality assessment schemes with a compromise between biological variation and state of the art. Clin. Chem. Lab. Med. 2012 50(5), 833-839.

Markowski, D., Helmke, B., Radtke, A., Froeb, J., Belge, G., Bartnitzke, S., Wosniok, W., Czybulka-Jachertz, I., Deichert, U., Bullerdiek, J. (2012): Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium. BMC Women’s Health 2012 12:2.

Kammann, U., Lang, T., Wosniok, W. (2012): Biological effects monitoring in marine research. Environmental Sciences Europe 24:1. doi:10.1186/2190-4715-24-1.

Montalvo-Urquizo, J., Bobrov, P., Schmidt, A., Wosniok, W. (2011): Elastic responses of texturized microscale materials using FEM simulations and stochastic material properties. Mechanics of Materials, doi: 10.1016/j.mechmat.2011.11.008

M. Pieper, G. W. Eagleson, W. Wosniok, G. Schlosser (2011): Origin and segregation of cranial placodes in Xenopus laevis. Developmental Biology 360 257–275.

L. Kloth, G. Belge, K. Burchardt, S. Loeschke, W. Wosniok, X. Fu, R. Nimzyk, S. A. Mohamed, N. Drieschner, V. Rippe, J. Bullerdiek (2011): Decrease in thyroid adenoma associated (THADA) expression is a marker of dedifferentiation of thyroid tissue. BMC Clinical Pathology 2011 11:13, doi:10.1186/1472-6890-11-13.

P. Bobrov, J. Montalvo-Urquizo, J. Lütjens, W. Brannath, W. Wosniok, A. Schmidt, M. Hunkel (2011): Ein stochastisches Modell zur Rekonstruktion elastischer Eigenschaften für texturierte Metalle. In: O. Kraft, A. Haug, F. Vollertsen, S. Büttgenbach (Hrsg.): Kolloquium Mikroproduktion und Abschlusskolloquium SFB 499, 11. - 12. Oktober 2011, Karlsruhe. KIT SCIENTIFIC REPORTS 7591, 183-189.

R. Haeckel, W. Wosniok, N. Al Shareef (2011): Permissible performance limits of regression analyses in method comparisons. Clin. Chem. Lab. Med. 2011 49, DOI 10.1515/CCLM.2011.668

J. Lütjens, P. Bobrov, M. Hunkel, W. Wosniok (2011): Towards a distribution-based formulation of FEM for micro-scale components. Procedia Engineering (10) 1663–1669.

E. Gurr, F. Arzideh, G. Brandhorst, A. Gröning, R. Haeckel, T. Hoff, L. Roggenbuck, G. Schumann, B. Wolters, W. Wosniok (2011): Musterstandardarbeitsanweisung Präanalytik. J. Lab. Med. 35(1) 55–60.

F. Arzideh, W. Wosniok, R. Haeckel (2011): Indirect reference intervals of plasma and serum thyrotropin (TSH) concentrations from intra-laboratory data bases from several German and Italian medical centres. Clin. Chem. Lab. Med. 49(4) 659-664.

R. Haeckel, W. Wosniok (2011): A new concept to derive permissible limits for analytical imprecision and bias considering diagnostic requirements and technical state-of-the-art. Clin. Chem. Lab. Med. 49(4) 623–635.

R. Haeckel, W. Wosniok (2010): Observed, unknown distributions of clinical chemical quantities should be considered to be log-normal: a proposal. Clin. Chem. Lab. Med. 48(10) 1393-1396.

R. Haeckel, W. Wosniok (2010): Controversies on quotient reporting to standardize laboratory results. Clin. Chem. Lab. Med. 48(8) 1199-1201.

F. Hofmann, R. Epp, A. Kalchschmid, W. Kratz, L. Kruse, U. Kuhn, B. Maisch, E. Müller, S. Ober, J. Radtke, U. Schlechtriemen, G. Schmidt, W. Schröder, W. v. d. Ohe, R. Vögel, N. Wedl, W. Wosniok (2010): Monitoring of Bt-Maize pollen exposure in the vicinity of the nature reserve Ruhlsdorfer Bruch in northeast Germany 2007 to 2008. Umweltwiss Schadst Forsch (22) 229–251.

D.N. Markowski, I. von Ahsen, M.H. Nezhad, B.M. Helmke, J. Bullerdiek, W. Wosniok (2010): HMGA2 and the p19(Arf)-TP53-CDKN1A Axis: A Delicate Balance in the Growth of Uterine Leiomyomas. Genes Chromosomes & Cancer 49(8) 661-668.

R. Haeckel, W. Wosniok, G. Hoffmann (2010): Standardisierung von Laborergebnissen: Ergebnisquotient. J. Lab. Med. 34(2) (2010) 95-98.

F. Arzideh, W. Wosniok, R. Haeckel (2010): Reference limits of plasma and serum creatinine concentrations from intra-laboratory data bases of several German and Italian medical centres Comparison between direct and indirect procedures. Clinica Chimica Acta 411 (2010) 215-221.

Haeckel, R; Wosniok, W. (2009): Quantity quotient reporting. A proposal for a standardized presentation of laboratory results. Clin. Chem. Lab. Med. 47(10) 1203-1206.

C. Karsten, S. Baumgarte, A.W. Friedrich, C. von Eiff, K. Becker, W. Wosniok, A. Ammon, J. Bockemühl, H. Karch, H.-I. Huppertz (2009): Incidence and risk factors for community-acquired gastroenteritis in North-West Germany in 2004. Eur J Clin Microbiol Infect Dis. DOI 10.1007/s10096-009-0729-1.

Arzideh, F; Gurr, E; Haeckel, R, et al. (2009): Guide values for quantitative examinations in medical laboratories: definitions, classification, and limits of application. Recommendations for classifying and defining guide values of quantitative measurements. Laboratoriumsmedizin - Journal of laboratory medicine 33 (4) 228-232.

U. Kammann, M. Vobach, W. Wosniok, A. Schäffer, A. Telscher(2009): Acute toxicity of 353-nonylphenol and its metabolites for zebrafish embryos (vol 16 pg 227, 2009). Environ Sci Pollut Res. 16(3) 365.

U. Kammann, M. Vobach, W. Wosniok, A. Schäffer, A. Telscher(2009): Acute toxicity of 353-nonylphenol and its metabolites for zebrafish embryos. Environ Sci Pollut Res. 16(2) 227-231.

R. Haeckel, W. Wosniok, F. Arzideh (2009): Proposed classification of various limit values (guide values) used in assisting the interpretation of quantitative laboratory test results. Clin Chem Lab Med 47(4) 494-497.

F. Arzideh, G. Brandhorst, E. Gurr, W. Hinsch, T. Hoff, L. Roggenbuck, G. Rothe, G. Schumann, B. Wolters, W. Wosniok, R. Haeckel (2009): An improved indirect approach for determining reference limits from intra-laboratory data bases exemplified by concentrations of electrolytes. J Lab Med 33(2) 52-66 (DOI 10.1515/JLM.2009.015)

K.-D. Clausnitzer, J. Gabriel, N. Diefenbach, T. Loga, W. Wosniok (2009): Was bewirkt das KfW-Programm? IKZ-Haustechnik 5/2009, 26-28.

F. Hofmann, R. Epp, A. Kalchschmid, L. Kruse, U. Kuhn, B. Maisch, E. Müller, S. Ober, J. Radtke, U. Schlechtriemen, G. Schmidt, W. Schröder, W. v.d. Ohe, R. Vögel, N. Wedl, W. Wosniok (2008): GVO-Pollenmonitoring zum Bt-Maisanbau im Bereich des NSG/FFH-Schutzgebietes Ruhlsdorfer Bruch. Umweltwiss Schadst Forsch (20) 275-289.

K.-D. Clausnitzer, J. Gabriel, N. Diefenbach, T. Loga, W.Wosniok (2008): Effekte des CO2-Programms. Bundesbaublatt 2 (2008) 42-45. Online: www.bundesbaublatt.de

K.-D. Clausnitzer, N. Diefenbach, J. Gabriel, T. Loga, W.Wosniok (2008): CO2-Gebäudesanierungsprogramm evaluiert - Schornsteinfeger übernahmen Prüfaufgaben. Schornsteinfegerhandwerk 1/2008, 5-11.

K.-D. Clausnitzer, N. Diefenbach, J. Gabriel, T. Loga, W.Wosniok (2008): Gebäudesanierungsprogramm forciert den Heizungstausch. Technik am Bau 3/2008, 80-82.

G. Belge, A. Meyer, M. Klemke, K. Burchardt, C. Stern, W. Wosniok, S. Loeschke, J. Bullerdiek (2008): HMGA2 as single marker for thyroid carcinomas. Virchows Archiv 452 S72-S74 Suppl. 1.

G. Belge, A. Meyer, M. Klemke, K. Burchardt, C. Stern, W. Wosniok, S. Loeschke, J. Bullerdiek (2008): HMGA2 as single marker for thyroid carcinomas. APMIS 116(3) 245.

G. Belge, A. Meyer, M. Klemke, K. Burchardt, C. Stern, W. Wosniok, S. Loeschke, J. Bullerdiek (2008): Upregulation of HMGA2 in thyroid carcinomas: a novel molecular marker to distinguish between benign and malignant follicular neoplasias. Genes Chromosomes Cancer 47(1), 56-63.

F. Arzideh, W. Wosniok, E. Gurr, W. Hinsch, G. Schumann, N. Weinstock and R. Haeckel (2007): A plea for intra-laboratory reference limits. Part 2. A bimodal retrospective concept for determining reference limits from intra-laboratory databases demonstrated by catalytic activity concentrations of enzymes. Clin. Chem. Lab. Med. 45(8), 1043-1057.

W. Wosniok, H. Aycil, J.-J. Lau, R. Stöver (2006): Mathematische Modelle zur Realisierung repräsentativer Bauschuttprobennahmen und ihre Überprüfung in der Praxis. Berichte aus der Technomathematik (06-08), Universität Bremen, ISSN 1435-7968.

T. Lang, W. Wosniok, J. Barsiene, K. Broeg, J. Kopecka, J. Parkkonen (2006): Liver histopathology in Baltic flounder (Platichthys flesus) as indicator of biological effects of contaminants. Marine Pollution Bulletin 53, 488-496.

G. Becker, W. Wosniok, S. Müller-Navarra (2006): Results of oceanographic observations and modelling of the German Bight. In: K. Hylland, T. Lang, D. Vethaak (eds.): Biological effects of contaminants in marine pelagic ecosystems. Society of Environmental Toxicology and Chemistry (SETAC), Brussels, 15-28.

R. Haeckel, R. Raber, W. Wosniok (2006): Comparability of indices for insulin resistance and insulin secretion determined during oral glucose tolerance tests. Clin. Chem. Lab. Med. 44(7), 817-823.

N. Reineke, S. Biselli, S. Franke, W. Francke, N. Heinzel, H. Hühnerfuss, H. Iznaguen, U. Kammann, N. Theobald, M. Vobach, W. Wosniok (2006): Brominated indoles and phenols in marine sediment and water extracts from the North and Baltic Seas - Concentrations and effects. Archives of environmental contamination and toxicology 51(2) 186-196.

U. Kammann, M. Vobach, W. Wosniok (2006): Toxic Effects of brominated indoles and phenols on zebrafish embryos. Archives of Environmental Contamination and Toxicology 51, 97-102.

R. Haeckel, W. Wosniok, F. Arzideh (2005): Festlegung von Entscheidungsgrenzen und Referenzbereichen. Klinische Chemie Mitteilungen 36(3/4), 51-55.

F. Hofmann, U. Schlechtriemen, W. Wosniok, M. Foth (2005): GVO-Pollenmonitoring. Technische und biologische Pollenakkumulatoren und PCR-Screening für ein Monitoring von gentechnisch veränderten Organismen. Hrsg: Bundesamt für Naturschutz, Bonn (BfN-Skripten 139), http://www.bfn.de.

U. Kammann, T. Lang, M. Vobach, W. Wosniok (2005): Ethoxyresorufin-O-deethylase (EROD) activity in dab (Limanda limanda) as biomarker for marine monitoring. Env Sci & Pollut Res 12(3) 140-145. OnlineFirst: DOI: http://dx.doi.org/10.1065/espr2004.12.228

U. Kammann, S. Biselli, N. Reineke, W. Wosniok, D. Danischewski, H. Hühnerfuss, A. Kinder, A. Sierts-Herrmann, N. Theobald, H.-H. Vahl, M. Vobach, J. Westendorf, H. Steinhart (2005): Bioassay-directed fractionation of organic extracts of marine surface sediments from the North and Baltic Sea - Part II: Results of the biotest battery and development of a biotest index. J. Soils & Sediments 5(4) 225-232. Online First: DOI: http://dx.doi.org/10.1065/jss2004.10.124.1

R. Haeckel, D. Colic, W. Wosniok (2004): Reference interval of serum insulin concentrations. Clin. Chem. Lab. Med. 42(9), 1069-1070.

R.Haeckel, W. Wosniok (2004): The phenomenon of regression-towards-the-mean. Clin. Chem. Lab. Med. 42(2), 241-241.

R.Haeckel, W. Wosniok (2004): The discordance rate, a new concept for combining diagnostic decisions with analytical performance characteristics. 2. Defining analytical goals applied to the diagnosis of type 2 diabetes by blood glucose concentrations. Clin. Chem. Lab. Med. 42(2), 198-203.

A.M. Flohr, P. Rogalla, U. Bonk, B. Puettmann, H. Buerger, G. Gohla, J. Packeisen, W. Wosniok, S. Loeschke, J. Bullerdiek (2003): High mobility group protein HMGA1 expression in breast cancer reveals a positive correlation with tumour grade. Histol. Histopathol. 18, 999-1004.

A.M. Flohr, P. Rogalla, U. Bonk, B.Püttmann, H. Burger, G. Gohla, J. Packeisen, W. Wosniok, S. Löschke, J. Bullerdiek (2003): High mobility group protein HMGA1 expression in breast cancer reveals a positive correlation with tumour grade. Histology and Histopathology 57(3-4), 999-1004.

R. Haeckel, W. Wosniok, R. Raber, H.U. Janka (2003): Proposal for detecting type-2 diabetes by a single post-challenge blood sample at lower decision limits. Clin. Chem. Lab. Med. 41(9), 1251-1258.

I. Püntmann, W. Wosniok, R. Haeckel (2003): Comparison of several Point-of-Care Testing (POCT) glucometers with an established laboratory procedure for the diagnosis of type 2 diabetes using the discordance rate. A new statistical approach. Clin. Chem. Lab. Med. 41(6), 809-820.

T. Lang, W. Wosniok (2003): EFFSTAT. Synthese und Analyse von marinen Daten über biologische Effekte und deren Ursachen mit Hilfe neuer statistischer Verfahren. Abschlussbericht zum BMBF-Projekt 03F0264A. Siehe auch www.bfa-fish.de/news/news-d/index.html .

C. Beardsley, J. Pernthaler, W. Wosniok, R. Amann (2003): Are readily culturable bacteria in coastal North Sea waters suppressed by selective grazing mortality? Applied and Environmental Microbiology 69(5), 2624-2630.

R. Haeckel, W. Wosniok, I. Püntmann (2003): Discordance rate, a new concept for combining diagnostic decisions with analytical performance characteristics. 1. Application in method or sample system comparisons and in defining decision limits. Clin. Chem. Lab. Med. 41(3), 347-355.

H. von Westernhagen, V. Dethlefsen, T. Bade, W. Wosniok (2002): Species assemblages of pelagic fish embryos in the southern North Sea betweeen 1984 and 2000. Helgol. Mar. Res. 55, 242-251.

U. Kammann, M. Vobach, W. Wosniok (2002): Entwicklung einer statistischen Auswertung für den Fischei-Test. In: Jahresbericht für 2001 der Bundesforschungsanstalt für Fischerei, Hamburg, 48-59.

N. Weis, U. Thurmann, W.Wosniok (2001): Probenahmeverfahren für geschredderte Gebrauchtholzsortimente. Holz als Roh- und Werkstoff 59, 1-8.

F. Hofmann, U. Schlechtriemen, W. Wosniok, U. Siemers, G. Bracke, A. Giesemann, M. Duve (2001): Luftgüte-Rindenmonitoring. Ein neues Probenahmegerät und Verfahren zum Biomonitoring von Luftschadstoffen für akkumulierbare Substanzen mit der Möglichkeit des Fingerprintings von Immissionsquellen. ecomed, Landsberg, VIII + 156.

Lacorn, M., Piechotta, G., Simat, T.J., Kammann, U., Wosniok, W., Lang, T., Müller, E.G., Schröder, H.C., Jenke, H.-S., Steinhart, H. (2001): Annual cycles of apoptosis, DNA strand breaks, heatshock proteins, and metallothionein isoforms in dab (Limanda limanda): influences of natural factors and consequences for biological effect monitoring. Biomarkers 6(2), 108-126.

Lang, T., Wosniok, W. (2000): ICES data for an holistic analysis of fish disease prevalence. In: ICES 2000, Report of the ICES Advisory Committee on the Marine Environment, 1999. ICES Coop. Res. Rep. 239: 193-209.

M. Lelgemann, A. Vagt, M. Fahr, W. Wosniok, P.S. Schönhöfer (2000): Symptomatisches Ulcus ventriculi unter Rofecoxib (Vioxx) - Datenlage zur Häufigkeit symptomatischer, schwerwiegender Störungen im oberen Gastrointestintestinaltrakt. Internistische Praxis 40, 647-654.

Wosniok, W. (2000): Statistische Methoden in der Medizin: Das Beispiel der Bewertung kardiologischer Risiken. In: Lison, A.E., Diehl, H.A. (Hrg.): Medizinische Forschung und Gesundheitswissenschaften in  Bremen, S. 329-336, Pabst Science Publishers, Lengerich.

Wosniok, W., Kitsos, C., Watanabe, K. (1999): Statistical issues in the application of multistage and biologically based models. In: Cogliano,V.C., Luebeck, E.G., Zapponi, G.A. (eds.): Perspectives on Biologically Based Cancer Risk Assessment, ch. 7, p. 243-274. Kluwer Academic / Plenum Publishers,  New York.

W. Wosniok, T. Lang, V. Dethlefsen (1999): Fischkrankheiten als Indikatoren für den Zustand der Nordsee. Universität Bremen, Impulse 27, 22-25

T. Lang, S. Mellergaard, W. Wosniok, V. Kadakas, K. Neumann (1999): Spatial distribution of grossly visible diseases and parasites in flounder (Platichthys flesus): a synoptic survey. ICES Journal of Marine Science 56, 138-147

W. Wosniok, T. Lang, A.D. Vethaak, S. des Clers and S. Mellergaard (1999): Statistical analysis of fish disease prevalence data extracted from the ICES Environmental Data Centre. In: ICES Cooperative Research Report No. 233, 297-327.

Wosniok, W. (1998): Die Bedeutung mathematischer Modelle für die Abschätzung kleiner Carcinogenese-Risiken. In: Preuss, V. (Hrg.): Risikoanalysen, Band 2. Asanger Verlag, Heidelberg, 321-333.

F. Hofmann, U. Schlechtriemen, W. Wosniok, S. Reckel (1998): Integrated monitoring for identifying the specific air pollution impacts of industrial emission sources. In: V. Stravienskiene, R. Juknys (eds.): Dendrochronology and environmental trends. Proceedings of the International Conference EuroDendro 1998, Vytautas Magnus Univ., Kaunas, Litauen, 160-168.

Krooß, J., Stolz, P., Thurmann, U., Wosniok, W., Peek, R.-D., Giese, H. (1998): Statistisch ermittelte Hintergrundkonzentrationen für Schwermetall- und Holzschutzmittel-Wirkstoffgehalte naturbelassener Althölzer. Holz-Zentralblatt 46 (1998), 689-695

Vicker, M.G., Xiang, W., Plath, P.J., Wosniok, W. (1997): Pseudopodium extension and amoeboid locomotion in Dictyostelium discoideum: Possible autowave behaviour of F-actin. Physica D 101, 317-332.

Wosniok, W. (1996): Die sichere Unsicherheit der Risikoabschätzung. In: Preuss, V. (Hrg.): Risikoanalysen. Asanger Verlag, Heidelberg, 22-32.

Busch, D.; Cetinkaya, M.; Wosniok, W. (1995): Die Belastung von Brassen (Abramis brama) mit Schwermetallen und schwerflüchtigen Organochlorverbindungen im bremischen Teil der Weser, 1985 und 1987. Teil I: Schwermetalle. In: Gerken, B.; Schirmer, M.; (Hrsg.): Limnologie aktuell, Band 6, Gustav Fischer Verlag, Stuttgart, 123 - 138.

Cetinkaya, M.; Balzer, W.; Busch, D.; Warnke, T.; Weigel, H.P.; Wosniok, W. (1995): Die Belastung von Brassen (Abramis brama) mit Schwermetallen und schwerflüchtigen Organochlorverbindungen im bremischen Teil der Weser 1985 und 1987, Teil II : Rückstände von Organochlorpestiziden und PCB. In: Gerken, B.; Schirmer, M. (Hrsg.): Limnologie aktuell, Band 6. Gustav Fischer Verlag, Stuttgart, 139 - 150.

Wosniok, W. (1993): Outlier detection. In: Haeckel, R. (ed.): Evaluation methods in laboratory medicine. VCH Verlagsgesellschaft, Weinheim, 227-237.

Wosniok, W. (1993): Dose-response models for cancer-inducing agents. In: B. Seifert (Hrsg): NATO/CCMS Pilot Study on Indoor Air Quality and European Collaborative Action: Report on a Joint workshop on Methods of risk assessment for the indoor Environment. Institute for Water, Soil and Air Hygiene of the Federal Health Office, Berlin, 29-46

Wosniok, W. (1993): Statistische Methoden im maritimen Umweltschutz. Universität Bremen, Impulse 16, 9-12.

C.S. Kurz, W. Wosniok, P. Harms (1993): Evaluation of clinical significance of Doppler indices for monitoring of high-risk pregnancies. Archives of Gynecology and Obstetrics 254 (1-4), 1505-1506.

H. Dudwiesus, R. Krieg, K.J. Schmidt, A. Gans, H. Fendel, R. Warnking, J. Pensel, W. Wosniok, C.S. Kurz, P. Harms, K.G. Schmidt (1993): Physical principles and techniques - assessment of instrumentation and Doppler wave forms. In: C. Sohn, W. Stolz, G. Bastert (eds.): Doppler ultrasonography in obstetrics and gynecology, 1-27.

Busch, D.; Lucker, T.; Schirmer, M.; Wosniok, W. (1992): The application of the bivalve Dreissena Polymorpha (Pallas) for biomonitoring routine of heavy metals in rivers. In: Neumann, Jenner (eds.): Limnologie aktuell, Band 4: The zebra musssel Dreissena polymorpha. Gustav Fischer Verlag, Stuttgart, 197-211.

Wosniok, W.; Kurz, C.S.; Harms, P. (1993): Zur Beurteilung der klinischen Wertigkeit von Doppler-Indices. In : Sohn, Ch.; Bastert, G. (Hrsg.): Dopplersonographie in der Gynäkologie und Geburtshilfe. Thieme-Verlag, 22-24.

Wosniok, W. (1993): Statistische Modelle der Carcinogenese. In : Kinder, H.-P.; Liese, F. (Hrsg.): 1. Rostock-Bremen-Statistik-Seminar, Rostock 1992, Tagungsbericht. Mathematik-Arbeitspapiere. Serie A : Math. Forschungspapiere, Universität Bremen, 50-59.

Kurz, C.S., Wosniok, W., Harms, P. (1992): Clinical assessment of fetal blood flow velocimetry. Gynäkol. Geburtsh. Rundschau 32, 215-221.

Wosniok, W., Kurz, C.S., Harms, P. (1992): Statistisches Verfahren zur Klassifikation eines klinischen Kollektivs von dopplersonographisch überwachten Schwangeren. In: Fendel, H. (Hrsg.): Perinatale Dopplerdiagnostik. Steinkopff Verlag, Darmstadt, 153-163.

Danker-Hopfe, H., Wosniok, W. (1991): The method of probits in auxology. Anthrop. Közl. 33, 113-122.

P. Harms, C.S. Kurz, W. Wosniok (1991): Diagnostic value of qualitative Doppler ultrasonography in monitoring pregnancies. Archives of Gynecology and Obstetrics, 250 (1-4), 629-630.

Fleischer, J., Wosniok, W. (1991): Die Wirkungen des Verbalisierens des Denkens auf die Lösung von Problemaufgaben. Empirische Pädagogik, 5(2), 105-132.

Nyiredy, S., Wosniok, W., Thiele, H., Sticher, O. (1991): ''PRISMA'' model for computer aided mobile phase optimization based on an automatic peak identification approach. Journal of Liquid Chromatography, 14(16&17), 3077-3110.

C. Hoose, K. Eberhardt, W. Hartmann, W. Wosniok (1990): Short- and long-term results of tuberculosis therapy with a fixed combination of isoniazide, prothionamide and diaminodiphenylsulfone combined with rifampicin. Pneumologie 44 Suppl. 1, 458-459.

Wenzel-Hartung, R.; Brune, H.; Grimmer, G.; Germann, P.; Timm, J.; Wosniok, W. (1990): Evaluation of the carcinogenic potency of 4 environmental polycyclic aromatic compounds following intrapulmonary application in rats. Exp. Pathol., 40, 221-227.

Scherer, H.E., Lindner, K., Wosniok, W., Engel, H.-J. (1990): Hämodynamische und klinische Ergebnisse nach perkutaner Aortenklappenvalvuloplastie bei Erwachsenen. Zeitschrift für Kardiologie, 79, 489-498.

Wosniok,W. (1987): Estimation of individual growth curves from aggregate data. In: Möller, D.P.F (Hrsg.): System analysis of biological processes. Vieweg, Braunschweig/ Wiesbaden, 133-139.

Astheimer, H., Wosniok, W. (1984): Individual- und Populationswachstum des antarktischen Krills (Euphausia superba). In: Möller, D.P.F., (Hrsg.): Systemanalyse biologischer Prozesse. Springer-Verlag Berlin Heidelberg, 78-83.

Drescher, K., Timm, J., Wosniok, W. (1982): Mathematische Aspekte der Risiko-Abschätzung im unteren Dosisbereich. In: Beurteilung des Risikos kleiner Dosen von krebserzeugenden Stoffen für den Menschen. Umweltbundesamt Berichte 1982. Erich Schmidt Verlag, Berlin,45-63.

Petrat, G., Steinforth, H., Timm, J., Wosniok, W. (1977): Prozessorientierter Unterricht. Franz Ehrenwirth Verlag, München.