Delf Lachmund

Research Areas

• Signal and image processing
• Numerical methods
• Imaging mass spectrometry

Projects

1. BMBF-MPI²: Model-based parameter identification in magnetic particle imaging (01.12.2016 - 30.11.2019)
2. Magnetic Particle Imaging (since 01.03.2016)
3. BMBF-MaDiPath: Mass spectrometric profiling and grading for oncologic routine applications in pathology (01.10.2015 - 30.09.2018)
4. Quality assessment of MALDI imaging data (since 01.04.2015)
5. Nicht-negative Matrix-Faktorisierung mit A-priori-Wissen (since 01.12.2014)
6. Entwicklung eines Digital-Staining-Verfahrens als pathologisch-histologisches Diagnosewerkzeug auf Basis der MALDI-Imaging-Technologie (01.07.2014 - 30.06.2016)

Courses (Selection)complete list

1. Übungen Numerik 1 (Wintersemester 2014/2015)

Theses (Selection)complete list

1. Klassifizierung von MALDI-Daten mit linearer Regression (Norbert Maager)
2. Klassifikation auf MALDI-Daten mit nichtnegativer Matrixfaktorisierung und überwachtem Lernen (Maximilian Schmidt)

Publications (Selection)complete list

1. T. Boskamp, D. Lachmund, R. Casadonte, L. Hauberg-Lotte, J. H. Kobarg, J. Kriegsmann, P. Maaß.
   Using the chemical noise background in MALDI mass spectrometry imaging for mass alignment and calibration.
   Analytical Chemistry, 92(1):1301-1308, 2020.

   DOI: 10.1021/acs.analchem.9b04473
   online at: https://doi.org/10.1021/acs.analchem.9b04473

2. J. Leuschner, M. Schmidt, P. Fernsel, D. Lachmund, T. Boskamp, P. Maaß.
   Supervised Non-negative Matrix Factorization Methods for MALDI Imaging Applications.
   Bioinformatics, bty909 , 2018.

   DOI: 10.1093/bioinformatics/bty909

3. Y. Cordero Hernandez, T. Boskamp, R. Casadonte, L. Hauberg-Lotte, J. Oetjen, D. Lachmund, A. Peter, D. Trede, K. Kriegsmann, M. Kriegsmann, J. Kriegsmann, P. Maaß.
   Targeted Feature Extraction in MALDI Mass Spectrometry Imaging to Discriminate Proteomic Profiles of Breast and Ovarian Cancer.
   Proteomics - Clinical Applications, 1700168 , Wiley, 2018.

   DOI: 10.1002/prca.201700168

4. J. Oetjen, D. Lachmund, A. Palmer, F. Alexandrov, M. Becker, T. Boskamp, P. Maaß.
   An approach to optimize sample preparation for MALDI imaging MS of FFPE sections using fractional factorial design of experiments.
   Analytical and Bioanalytical Chemistry, 408(24):6729-40, 2016.

   DOI: 10.1007/s00216-016-9793-4

5. T. Boskamp, D. Lachmund, J. Oetjen, Y. Hernandez-Cordero, D. Trede, P. Maaß, R. Casadonte, J. Kriegsmann, A. Warth, H. Dienemann, W. Weichert, M. Kriegsmann.
   A new classification method for MALDI imaging mass spectrometry data acquired on formalin-fixed paraffin-embedded tissue samples.
   BBA - Proteins and Proteomics, , 2016.

   DOI: 10.1016/j.bbapap.2016.11.003